Reduced Lipid Bilayer Thickness Regulates the Aggregation and Cytotoxicity of Amyloid-β

The aggregation of amyloid-β (Aβ) on lipid bilayers has been implicated as a mechanism by which Aβ exerts its toxicity in Alzheimer's disease (AD). Lipid bilayer thinning has been observed during both oxidative stress and protein aggregation in AD, but whether these pathological modifications o...

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Vydáno v:J Biol Chem
Hlavní autoři: Korshavn, Kyle J., Satriano, Cristina, Lin, Yuxi, Zhang, Rongchun, Dulchavsky, Mark, Bhunia, Anirban, Ivanova, Magdalena I., Lee, Young-Ho, La Rosa, Carmelo, Lim, Mi Hee, Ramamoorthy, Ayyalusamy
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2017
Témata:
Protein Structure and Folding
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5377779/
https://ncbi.nlm.nih.gov/pubmed/28154182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.764092
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