Reduced Lipid Bilayer Thickness Regulates the Aggregation and Cytotoxicity of Amyloid-β

The aggregation of amyloid-β (Aβ) on lipid bilayers has been implicated as a mechanism by which Aβ exerts its toxicity in Alzheimer's disease (AD). Lipid bilayer thinning has been observed during both oxidative stress and protein aggregation in AD, but whether these pathological modifications o...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Korshavn, Kyle J., Satriano, Cristina, Lin, Yuxi, Zhang, Rongchun, Dulchavsky, Mark, Bhunia, Anirban, Ivanova, Magdalena I., Lee, Young-Ho, La Rosa, Carmelo, Lim, Mi Hee, Ramamoorthy, Ayyalusamy
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2017
Materias:
Protein Structure and Folding
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5377779/
https://ncbi.nlm.nih.gov/pubmed/28154182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.764092
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