Amyloid-β adopts a conserved, partially folded structure upon binding to zwitterionic lipid bilayers prior to amyloid formation

Por Korshavn, Kyle, Bhunia, Anirban, Lim, Mi Hee, Ramamoorthy, Ayyalusamy
Publicado no Chem Commun (Camb) (2016)

A Small Molecule that Displays Marked Reactivity with Copper– versus Zinc–Amyloid-β Implicated in Alzheimer’s Disease

Por Savelieff, Masha G., Liu, Yuzhong, Senthamarai, Russell R. P., Korshavn, Kyle J., Lee, Hyuck Jin, Ramamoorthy, Ayyalusamy, Lim, Mi Hee
Publicado em 2013

Reactivity of Metal-Free and Metal-Associated Amyloid-β with Glycosylated Polyphenols and Their Esterified Derivatives

Por Korshavn, Kyle J., Jang, Milim, Kwak, Yeon Ju, Kochi, Akiko, Vertuani, Silvia, Bhunia, Anirban, Manfredini, Stefano, Ramamoorthy, Ayyalusamy, Lim, Mi Hee
Publicado no Sci Rep (2015)

Reduced Lipid Bilayer Thickness Regulates the Aggregation and Cytotoxicity of Amyloid-β

Por Korshavn, Kyle J., Satriano, Cristina, Lin, Yuxi, Zhang, Rongchun, Dulchavsky, Mark, Bhunia, Anirban, Ivanova, Magdalena I., Lee, Young-Ho, La Rosa, Carmelo, Lim, Mi Hee, Ramamoorthy, Ayyalusamy
Publicado no J Biol Chem (2017)

Multi-target-directed phenol–triazole ligands as therapeutic agents for Alzheimer's disease

Por Jones, Michael R., Mathieu, Emilie, Dyrager, Christine, Faissner, Simon, Vaillancourt, Zavier, Korshavn, Kyle J., Lim, Mi Hee, Ramamoorthy, Ayyalusamy, Wee Yong, V., Tsutsui, Shigeki, Stys, Peter K., Storr, Tim
Publicado no Chem Sci (2017)

A Redox-Active, Compact Molecule for Cross-Linking Amyloidogenic Peptides into Nontoxic, Off-Pathway Aggregates: In Vitro and In Vivo Efficacy and Molecular Mechanisms

Por Derrick, Jeffrey S., Kerr, Richard A., Nam, Younwoo, Oh, Shin Bi, Lee, Hyuck Jin, Earnest, Kaylin G., Suh, Nayoung, Peck, Kristy L., Ozbil, Mehmet, Korshavn, Kyle J., Ramamoorthy, Ayyalusamy, Prabhakar, Rajeev, Merino, Edward J., Shearer, Jason, Lee, Joo-Yong, Ruotolo, Brandon T., Lim, Mi Hee
Publicado no J Am Chem Soc (2015)