A Redox-Active, Compact Molecule for Cross-Linking Amyloidogenic Peptides into Nontoxic, Off-Pathway Aggregates: In Vitro and In Vivo Efficacy and Molecular Mechanisms

Chemical reagents targeting and controlling amyloidogenic peptides have received much attention for helping identify their roles in the pathogenesis of protein-misfolding disorders. Herein, we report a novel strategy for redirecting amyloidogenic peptides into nontoxic, off-pathway aggregates, which...

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Publicado no:J Am Chem Soc
Main Authors: Derrick, Jeffrey S., Kerr, Richard A., Nam, Younwoo, Oh, Shin Bi, Lee, Hyuck Jin, Earnest, Kaylin G., Suh, Nayoung, Peck, Kristy L., Ozbil, Mehmet, Korshavn, Kyle J., Ramamoorthy, Ayyalusamy, Prabhakar, Rajeev, Merino, Edward J., Shearer, Jason, Lee, Joo-Yong, Ruotolo, Brandon T., Lim, Mi Hee
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4758209/
https://ncbi.nlm.nih.gov/pubmed/26575890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b10043
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