A Redox-Active, Compact Molecule for Cross-Linking Amyloidogenic Peptides into Nontoxic, Off-Pathway Aggregates: In Vitro and In Vivo Efficacy and Molecular Mechanisms

Chemical reagents targeting and controlling amyloidogenic peptides have received much attention for helping identify their roles in the pathogenesis of protein-misfolding disorders. Herein, we report a novel strategy for redirecting amyloidogenic peptides into nontoxic, off-pathway aggregates, which...

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Veröffentlicht in:J Am Chem Soc
Hauptverfasser: Derrick, Jeffrey S., Kerr, Richard A., Nam, Younwoo, Oh, Shin Bi, Lee, Hyuck Jin, Earnest, Kaylin G., Suh, Nayoung, Peck, Kristy L., Ozbil, Mehmet, Korshavn, Kyle J., Ramamoorthy, Ayyalusamy, Prabhakar, Rajeev, Merino, Edward J., Shearer, Jason, Lee, Joo-Yong, Ruotolo, Brandon T., Lim, Mi Hee
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4758209/
https://ncbi.nlm.nih.gov/pubmed/26575890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b10043
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