Target Enzymes Considered for the Treatment of Alzheimer's Disease and Parkinson's Disease

由 Kim, Namdoo, Lee, Hyuck Jin
發表在 Biomed Res Int (2020)

Redox-Active Metal Ions and Amyloid-Degrading Enzymes in Alzheimer’s Disease

由 Kim, Namdoo, Lee, Hyuck Jin
發表在 Int J Mol Sci (2021)

Mechanistic approaches for chemically modifying the coordination sphere of copper–amyloid-β complexes

由 Han, Jiyeon, Lee, Hyuck Jin, Kim, Kyu Yeon, Nam, Geewoo, Chae, Junghyun, Lim, Mi Hee
發表在 Proc Natl Acad Sci U S A (2020)

Tailoring Hydrophobic Interactions between Probes and Amyloid-β Peptides for Fluorescent Monitoring of Amyloid-β Aggregation

由 Kim, Sonam, Lee, Hyuck Jin, Nam, Eunju, Jeong, Donghyun, Cho, Jaeheung, Lim, Mi Hee, You, Youngmin
發表在 ACS Omega (2018)

Chemical strategies to modify amyloidogenic peptides using iridium(iii) complexes: coordination and photo-induced oxidation

由 Kang, Juhye, Nam, Jung Seung, Lee, Hyuck Jin, Nam, Geewoo, Rhee, Hyun-Woo, Kwon, Tae-Hyuk, Lim, Mi Hee
發表在 Chem Sci (2019)

Multiple reactivities of flavonoids towards pathological elements in Alzheimer's disease: structure–activity relationship

由 Nam, Geewoo, Hong, Mannkyu, Lee, Juri, Lee, Hyuck Jin, Ji, Yonghwan, Kang, Juhye, Baik, Mu-Hyun, Lim, Mi Hee
發表在 Chem Sci (2020)

A Small Molecule that Displays Marked Reactivity with Copper– versus Zinc–Amyloid-β Implicated in Alzheimer’s Disease

由 Savelieff, Masha G., Liu, Yuzhong, Senthamarai, Russell R. P., Korshavn, Kyle J., Lee, Hyuck Jin, Ramamoorthy, Ayyalusamy, Lim, Mi Hee
出版 2013

Aconitine Neurotoxicity According to Administration Methods

由 Chung, Ji Yeon, Lee, Seung Jae, Lee, Hyuck Jin, Bong, Jeong Bin, Lee, Chan-Hyuk, Shin, Byoung-Soo, Kang, Hyun Goo
發表在 J Clin Med (2021)

Impact of sphingosine and acetylsphingosines on the aggregation and toxicity of metal-free and metal-treated amyloid-β

由 Yi, Yelim, Lin, Yuxi, Han, Jiyeon, Lee, Hyuck Jin, Park, Nahye, Nam, Geewoo, Park, Young S., Lee, Young-Ho, Lim, Mi Hee
發表在 Chem Sci (2020)

A rationally designed small molecule for identifying an in vivo link between metal–amyloid-β complexes and the pathogenesis of Alzheimer's disease

由 Beck, Michael W., Oh, Shin Bi, Kerr, Richard A., Lee, Hyuck Jin, Kim, So Hee, Kim, Sujeong, Jang, Milim, Ruotolo, Brandon T., Lee, Joo-Yong, Lim, Mi Hee
發表在 Chem Sci (2015)

Structure and assembly mechanisms of toxic human islet amyloid polypeptide oligomers associated with copper

由 Lee, Shin Jung C., Choi, Tae Su, Lee, Jong Wha, Lee, Hyuck Jin, Mun, Dong-Gi, Akashi, Satoko, Lee, Sang-Won, Lim, Mi Hee, Kim, Hugh I.
發表在 Chem Sci (2016)

Monitoring metal–amyloid-β complexation by a FRET-based probe: design, detection, and inhibitor screening

由 Lee, Hyuck Jin, Lee, Young Geun, Kang, Juhye, Yang, Seung Hyun, Kim, Ju Hwan, Ghisaidoobe, Amar B. T., Kang, Hyo Jin, Lee, Sang-Rae, Lim, Mi Hee, Chung, Sang J.
發表在 Chem Sci (2018)

Correction: Monitoring metal–amyloid-β complexation by a FRET-based probe: design, detection, and inhibitor screening

由 Lee, Hyuck Jin, Lee, Young Geun, Kang, Juhye, Yang, Seung Hyun, Kim, Ju Hwan, Ghisaidoobe, Amar B. T., Kang, Hyo Jin, Lee, Sang-Rae, Lim, Mi Hee, Chung, Sang J.
發表在 Chem Sci (2019)

Synthetic Flavonoids, Aminoisoflavones: Interaction and Reactivity with Metal-Free and Metal-Associated Amyloid-β Species

由 DeToma, Alaina S., Krishnamoorthy, Janarthanan, Nam, Younwoo, Lee, Hyuck Jin, Brender, Jeffrey R., Kochi, Akiko, Lee, Dongkuk, Onnis, Valentina, Congiu, Cenzo, Manfredini, Stefano, Vertuani, Silvia, Balboni, Gianfranco, Ramamoorthy, Ayyalusamy, Lim, Mi Hee
出版 2014

Structural and Mechanistic Insights into Development of Chemical Tools to Control Individual and Inter-Related Pathological Features in Alzheimer’s Disease

由 Lee, Hyuck Jin, Korshavn, Kyle J., Nam, Younwoo, Kang, Juhye, Paul, Thomas J., Kerr, Richard A., Youn, Il Seung, Ozbil, Mehmet, Kim, Kwang S., Ruotolo, Brandon T., Prabhakar, Rajeev, Ramamoorthy, Ayyalusamy, Lim, Mi Hee
發表在 Chemistry (2017)

Rational Design of a Structural Framework with Potential Use to Develop Chemical Reagents That Target and Modulate Multiple Facets of Alzheimer’s Disease

由 Lee, Sanghyun, Zheng, Xueyun, Krishnamoorthy, Janarthanan, Savelieff, Masha G., Park, Hyun Min, Brender, Jeffrey R., Kim, Jin Hoon, Derrick, Jeffrey S., Kochi, Akiko, Lee, Hyuck Jin, Kim, Cheal, Ramamoorthy, Ayyalusamy, Bowers, Michael T., Lim, Mi Hee
出版 2013

An Iridium(III) Complex as a Photoactivatable Tool for Oxidation of Amyloidogenic Peptides with Subsequent Modulation of Peptide Aggregation

由 Kang, Juhye, Lee, Shin Jung C., Nam, Jung Seung, Lee, Hyuck Jin, Kang, Myeong-Gyun, Korshavn, Kyle J., Kim, Hyun-Tak, Cho, Jaeheung, Ramamoorthy, Ayyalusamy, Rhee, Hyun-Woo, Kwon, Tae-Hyuk, Lim, Mi Hee
發表在 Chemistry (2017)

A Redox-Active, Compact Molecule for Cross-Linking Amyloidogenic Peptides into Nontoxic, Off-Pathway Aggregates: In Vitro and In Vivo Efficacy and Molecular Mechanisms

由 Derrick, Jeffrey S., Kerr, Richard A., Nam, Younwoo, Oh, Shin Bi, Lee, Hyuck Jin, Earnest, Kaylin G., Suh, Nayoung, Peck, Kristy L., Ozbil, Mehmet, Korshavn, Kyle J., Ramamoorthy, Ayyalusamy, Prabhakar, Rajeev, Merino, Edward J., Shearer, Jason, Lee, Joo-Yong, Ruotolo, Brandon T., Lim, Mi Hee
發表在 J Am Chem Soc (2015)