Optimization and Evaluation of Antiparasitic Benzamidobenzoic Acids as Inhibitors of a Kinetoplastid Hexokinase 1

Kinetoplastid-based infections are neglected diseases that represent a significant human health issue. Chemotherapeutic options are limited due to toxicity, parasite susceptibility, and poor patient compliance. In response, we studied a molecular target-directed approach involving intervention of he...

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Vydáno v:ChemMedChem
Hlavní autoři: Flaherty, Daniel P., Harris, Michael T., Schroeder, Chad E., Khan, Haaris, Kahney, Elizabeth W., Hackler, Amber L., Patrick, Stephen L., Weiner, Warren S., Aubé, Jeffrey, Sharlow, Elizabeth R., Morris, James C., Golden, Jennifer E.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5808564/
https://ncbi.nlm.nih.gov/pubmed/29105342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201700592
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