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Exploring the mode of action of ebselen in Trypanosoma brucei hexokinase inhibition()
Glycolysis is essential to Trypanosoma brucei, the causative agent of African sleeping sickness, suggesting enzymes in the pathway could be targets for drug development. Ebselen (2-phenyl-1,2-benzisoselenazol-3(2H)-one, EbSe) was identified in a screen as a potent inhibitor of T. brucei hexokinase 1...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3862409/ https://ncbi.nlm.nih.gov/pubmed/24533305 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpddr.2013.08.002 |
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