A Target-Based High Throughput Screen Yields Trypanosoma brucei Hexokinase Small Molecule Inhibitors with Antiparasitic Activity

BACKGROUND: The parasitic protozoan Trypanosoma brucei utilizes glycolysis exclusively for ATP production during infection of the mammalian host. The first step in this metabolic pathway is mediated by hexokinase (TbHK), an enzyme essential to the parasite that transfers the γ-phospho of ATP to a he...

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Detalhes bibliográficos
Main Authors: Sharlow, Elizabeth R., Lyda, Todd A., Dodson, Heidi C., Mustata, Gabriela, Morris, Meredith T., Leimgruber, Stephanie S., Lee, Kuo-Hsiung, Kashiwada, Yoshiki, Close, David, Lazo, John S., Morris, James C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2854128/
https://ncbi.nlm.nih.gov/pubmed/20405000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0000659
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