Optimization and Evaluation of Antiparasitic Benzamidobenzoic Acids as Inhibitors of a Kinetoplastid Hexokinase 1

Kinetoplastid-based infections are neglected diseases that represent a significant human health issue. Chemotherapeutic options are limited due to toxicity, parasite susceptibility, and poor patient compliance. In response, we studied a molecular target-directed approach involving intervention of he...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:ChemMedChem
Prif Awduron: Flaherty, Daniel P., Harris, Michael T., Schroeder, Chad E., Khan, Haaris, Kahney, Elizabeth W., Hackler, Amber L., Patrick, Stephen L., Weiner, Warren S., Aubé, Jeffrey, Sharlow, Elizabeth R., Morris, James C., Golden, Jennifer E.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5808564/
https://ncbi.nlm.nih.gov/pubmed/29105342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201700592
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