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Antiparasitic lethality of sulfonamidebenzamides in kinetoplastids
A sulfonamidebenzamide series was assessed for anti-kinetoplastid parasite activity based on structural similarity to the antiparasitic drug, nifurtimox. Through structure-activity optimization, derivatives with limited mammalian cell toxicity and increased potency toward African trypanosomes and Le...
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| Publicado no: | Bioorg Med Chem Lett |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5296257/ https://ncbi.nlm.nih.gov/pubmed/28119024 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2017.01.043 |
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