Discovery of Sulfonamidebenzamides as Selective Apoptotic CHOP Pathway Activators of the Unfolded Protein Response

[Image: see text] Cellular proteins that fail to fold properly result in inactive or disfunctional proteins that can have toxic functions. The unfolded protein response (UPR) is a two-tiered cellular mechanism initiated by eukaryotic cells that have accumulated misfolded proteins within the endoplas...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Flaherty, Daniel P., Miller, Justin R., Garshott, Danielle M., Hedrick, Michael, Gosalia, Palak, Li, Yujie, Milewski, Monika, Sugarman, Eliot, Vasile, Stefan, Salaniwal, Sumeet, Su, Ying, Smith, Layton H., Chung, Thomas D. Y., Pinkerton, Anthony B., Aubé, Jeffrey, Callaghan, Michael U., Golden, Jennifer E., Fribley, Andrew M., Kaufman, Randal J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4266338/
https://ncbi.nlm.nih.gov/pubmed/25530830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml5003234
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