Optimization and Evaluation of Antiparasitic Benzamidobenzoic Acids as Inhibitors of a Kinetoplastid Hexokinase 1

Kinetoplastid-based infections are neglected diseases that represent a significant human health issue. Chemotherapeutic options are limited due to toxicity, parasite susceptibility, and poor patient compliance. In response, we studied a molecular target-directed approach involving intervention of he...

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Bibliographic Details
Published in:ChemMedChem
Main Authors: Flaherty, Daniel P., Harris, Michael T., Schroeder, Chad E., Khan, Haaris, Kahney, Elizabeth W., Hackler, Amber L., Patrick, Stephen L., Weiner, Warren S., Aubé, Jeffrey, Sharlow, Elizabeth R., Morris, James C., Golden, Jennifer E.
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5808564/
https://ncbi.nlm.nih.gov/pubmed/29105342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201700592
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