Optimization and Evaluation of Antiparasitic Benzamidobenzoic Acids as Inhibitors of a Kinetoplastid Hexokinase 1

Kinetoplastid-based infections are neglected diseases that represent a significant human health issue. Chemotherapeutic options are limited due to toxicity, parasite susceptibility, and poor patient compliance. In response, we studied a molecular target-directed approach involving intervention of he...

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Détails bibliographiques
Publié dans:ChemMedChem
Auteurs principaux: Flaherty, Daniel P., Harris, Michael T., Schroeder, Chad E., Khan, Haaris, Kahney, Elizabeth W., Hackler, Amber L., Patrick, Stephen L., Weiner, Warren S., Aubé, Jeffrey, Sharlow, Elizabeth R., Morris, James C., Golden, Jennifer E.
Format: Artigo
Langue:Inglês
Publié: 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5808564/
https://ncbi.nlm.nih.gov/pubmed/29105342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201700592
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