Prophylactic Treatment with VT-1161 Protects Immunosuppressed Mice from Rhizopus arrhizus var. arrhizus Infection

We compared prophylactic or continuous therapy with the investigational drug VT-1161 to that with posaconazole in treating murine mucormycosis due to Rhizopus arrhizus var. arrhizus. In the prophylaxis studies, only VT-1161 resulted in improved survival and lowered tissue fungal burden of immunosupp...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Gebremariam, Teclegiorgis, Alkhazraji, Sondus, Lin, Lin, Wiederhold, Nathan P., Garvey, Edward P., Hoekstra, William J., Schotzinger, Robert J., Patterson, Thomas F., Filler, Scott G., Ibrahim, Ashraf S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5571349/
https://ncbi.nlm.nih.gov/pubmed/28652241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00390-17
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