Post-Translational Modifications (PTMs), Identified on Endogenous Huntingtin, Cluster within Proteolytic Domains between HEAT Repeats

Post-translational modifications (PTMs) of proteins regulate various cellular processes. PTMs of polyglutamine-expanded huntingtin (Htt) protein, which causes Huntington’s disease (HD), are likely modulators of HD pathogenesis. Previous studies have identified and characterized several PTMs on exoge...

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Detalhes bibliográficos
Publicado no:J Proteome Res
Main Authors: Ratovitski, Tamara, O’Meally, Robert N., Jiang, Mali, Chaerkady, Raghothama, Chighladze, Ekaterine, Stewart, Jacqueline C., Wang, Xiaofang, Arbez, Nicolas, Roby, Elaine, Alexandris, Athanasios, Duan, Wenzhen, Vijayvargia, Ravi, Seong, Ihn Sik, Lavery, Daniel J., Cole, Robert N., Ross, Christopher A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5560079/
https://ncbi.nlm.nih.gov/pubmed/28653853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jproteome.6b00991
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