Antitumor activity of the aurora a selective kinase inhibitor, alisertib, against preclinical models of colorectal cancer

BACKGROUND: The Aurora kinases are a family of serine/threonine kinases comprised of Aurora A, B, and C which execute critical steps in mitotic and meiotic progression. Alisertib (MLN8237) is an investigational Aurora A selective inhibitor that has demonstrated activity against a wide variety of tum...

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Bibliografski detalji
Izdano u:Oncotarget
Glavni autori: Pitts, Todd M., Bradshaw, Erica L., Bagby, Stacey M., Hyatt, Stephanie L., Selby, Heather M., Spreafico, Anna, Tentler, John J., McPhillips, Kelly, Klauck, Peter J., Capasso, Anna, Diamond, Jennifer R., Davis, S. Lindsey, Tan, Aik Choon, Arcaroli, John J., Purkey, Alicia, Messersmith, Wells A., Ecsedy, Jeffery A., Eckhardt, S. Gail
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2016
Teme:
Research Paper
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5226583/
https://ncbi.nlm.nih.gov/pubmed/27385211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10366
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