Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses

Checkpoint blockade with antibodies against CTLA-4 or PD-1 elicits durable tumor regressions in metastatic cancer, but these dramatic responses are confined to a minority of patients(1–3). This suboptimal outcome is likely due in part to the complex network of immunosuppressive pathways present in a...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Nat Med
Egile Nagusiak: Moynihan, Kelly D., Opel, Cary F., Szeto, Gregory L., Tzeng, Alice, Zhu, Eric F., Engreitz, Jesse M., Williams, Robert T., Rakhra, Kavya, Zhang, Michael H., Rothschilds, Adrienne M., Kumari, Sudha, Kelly, Ryan L., Kwan, Byron H., Abraham, Wuhbet, Hu, Kevin, Mehta, Naveen K., Kauke, Monique J., Suh, Heikyung, Cochran, Jennifer R., Lauffenburger, Douglas A., Wittrup, K. Dane, Irvine, Darrell J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2016
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5209798/
https://ncbi.nlm.nih.gov/pubmed/27775706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4200
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