Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses

Checkpoint blockade with antibodies against CTLA-4 or PD-1 elicits durable tumor regressions in metastatic cancer, but these dramatic responses are confined to a minority of patients(1–3). This suboptimal outcome is likely due in part to the complex network of immunosuppressive pathways present in a...

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Veröffentlicht in:Nat Med
Hauptverfasser: Moynihan, Kelly D., Opel, Cary F., Szeto, Gregory L., Tzeng, Alice, Zhu, Eric F., Engreitz, Jesse M., Williams, Robert T., Rakhra, Kavya, Zhang, Michael H., Rothschilds, Adrienne M., Kumari, Sudha, Kelly, Ryan L., Kwan, Byron H., Abraham, Wuhbet, Hu, Kevin, Mehta, Naveen K., Kauke, Monique J., Suh, Heikyung, Cochran, Jennifer R., Lauffenburger, Douglas A., Wittrup, K. Dane, Irvine, Darrell J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5209798/
https://ncbi.nlm.nih.gov/pubmed/27775706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4200
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