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Temporally Programmed CD8α(+) DC Activation Enhances Combination Cancer Immunotherapy

Numerous synergistic cancer immunotherapy combinations have been identified, but the effects of relative dose timing are rarely considered. In established syngeneic mouse tumor models, we found that staggering IFNα administration after, rather than before or simultaneously with, serum-persistent IL-...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Tzeng, Alice, Kauke, Monique J., Zhu, Eric F., Moynihan, Kelly D., Opel, Cary F., Yang, Nicole J., Mehta, Naveen, Kelly, Ryan L., Szeto, Gregory L., Overwijk, Willem W., Irvine, Darrell J., Wittrup, K. Dane
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5204262/
https://ncbi.nlm.nih.gov/pubmed/27926855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.11.020
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