Synergistic innate and adaptive immune response to combination immunotherapy with anti-tumor antigen antibodies and extended serum half-life IL-2

Cancer immunotherapies under development have generally focused on either stimulating T-cell immunity or driving antibody-directed effector functions of the innate immune system such as antibody-dependent cell-mediated cytotoxicity (ADCC). We find that a combination of an anti-tumor antigen antibody...

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Publicado no:Cancer Cell
Main Authors: Zhu, Eric F., Gai, Shuning A., Opel, Cary F., Kwan, Byron H., Surana, Rishi, Mihm, Martin C., Kauke, Monique J., Moynihan, Kelly D., Angelini, Alessandro, Williams, Robert T., Stephan, Matthias T., Kim, Jacob S., Yaffe, Michael B., Irvine, Darrell J., Weiner, Louis M., Dranoff, Glenn, Wittrup, K. Dane
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4398916/
https://ncbi.nlm.nih.gov/pubmed/25873172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2015.03.004
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