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Synergistic Antitumor Activity from Two-Stage Delivery of Targeted Toxins and Endosome-Disrupting Nanoparticles

[Image: see text] Plant-derived Type I toxins are candidate anticancer therapeutics requiring cytosolic delivery into tumor cells. We tested a concept for two-stage delivery, whereby tumor cells precoated with an antibody-targeted gelonin toxin were killed by exposure to endosome-disrupting polymer...

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Detalhes bibliográficos
Main Authors: Su, Xingfang, Yang, Nicole, Wittrup, K. Dane, Irvine, Darrell J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2013
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3646422/
https://ncbi.nlm.nih.gov/pubmed/23444913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bm3019906
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