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Synergistic Antitumor Activity from Two-Stage Delivery of Targeted Toxins and Endosome-Disrupting Nanoparticles
[Image: see text] Plant-derived Type I toxins are candidate anticancer therapeutics requiring cytosolic delivery into tumor cells. We tested a concept for two-stage delivery, whereby tumor cells precoated with an antibody-targeted gelonin toxin were killed by exposure to endosome-disrupting polymer...
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| Main Authors: | , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Chemical
Society
2013
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| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3646422/ https://ncbi.nlm.nih.gov/pubmed/23444913 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bm3019906 |
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