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Antigen specificity can be irrelevant to immunocytokine efficacy and biodistribution
Cytokine therapy can activate potent, sustained antitumor responses, but collateral toxicity often limits dosages. Although antibody–cytokine fusions (immunocytokines) have been designed with the intent to localize cytokine activity, systemic dose-limiting side effects are not fully ameliorated by a...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4371941/ https://ncbi.nlm.nih.gov/pubmed/25733854 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1416159112 |
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