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Antigen specificity can be irrelevant to immunocytokine efficacy and biodistribution
Cytokine therapy can activate potent, sustained antitumor responses, but collateral toxicity often limits dosages. Although antibody–cytokine fusions (immunocytokines) have been designed with the intent to localize cytokine activity, systemic dose-limiting side effects are not fully ameliorated by a...
Gardado en:
| Publicado en: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4371941/ https://ncbi.nlm.nih.gov/pubmed/25733854 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1416159112 |
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