Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses

Checkpoint blockade with antibodies against CTLA-4 or PD-1 elicits durable tumor regressions in metastatic cancer, but these dramatic responses are confined to a minority of patients(1–3). This suboptimal outcome is likely due in part to the complex network of immunosuppressive pathways present in a...

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書誌詳細
出版年:Nat Med
主要な著者: Moynihan, Kelly D., Opel, Cary F., Szeto, Gregory L., Tzeng, Alice, Zhu, Eric F., Engreitz, Jesse M., Williams, Robert T., Rakhra, Kavya, Zhang, Michael H., Rothschilds, Adrienne M., Kumari, Sudha, Kelly, Ryan L., Kwan, Byron H., Abraham, Wuhbet, Hu, Kevin, Mehta, Naveen K., Kauke, Monique J., Suh, Heikyung, Cochran, Jennifer R., Lauffenburger, Douglas A., Wittrup, K. Dane, Irvine, Darrell J.
フォーマット: Artigo
言語:Inglês
出版事項: 2016
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5209798/
https://ncbi.nlm.nih.gov/pubmed/27775706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4200
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