Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses

Checkpoint blockade with antibodies against CTLA-4 or PD-1 elicits durable tumor regressions in metastatic cancer, but these dramatic responses are confined to a minority of patients(1–3). This suboptimal outcome is likely due in part to the complex network of immunosuppressive pathways present in a...

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Publicado no:Nat Med
Main Authors: Moynihan, Kelly D., Opel, Cary F., Szeto, Gregory L., Tzeng, Alice, Zhu, Eric F., Engreitz, Jesse M., Williams, Robert T., Rakhra, Kavya, Zhang, Michael H., Rothschilds, Adrienne M., Kumari, Sudha, Kelly, Ryan L., Kwan, Byron H., Abraham, Wuhbet, Hu, Kevin, Mehta, Naveen K., Kauke, Monique J., Suh, Heikyung, Cochran, Jennifer R., Lauffenburger, Douglas A., Wittrup, K. Dane, Irvine, Darrell J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5209798/
https://ncbi.nlm.nih.gov/pubmed/27775706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4200
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