Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses

Checkpoint blockade with antibodies against CTLA-4 or PD-1 elicits durable tumor regressions in metastatic cancer, but these dramatic responses are confined to a minority of patients(1–3). This suboptimal outcome is likely due in part to the complex network of immunosuppressive pathways present in a...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Med
Prif Awduron: Moynihan, Kelly D., Opel, Cary F., Szeto, Gregory L., Tzeng, Alice, Zhu, Eric F., Engreitz, Jesse M., Williams, Robert T., Rakhra, Kavya, Zhang, Michael H., Rothschilds, Adrienne M., Kumari, Sudha, Kelly, Ryan L., Kwan, Byron H., Abraham, Wuhbet, Hu, Kevin, Mehta, Naveen K., Kauke, Monique J., Suh, Heikyung, Cochran, Jennifer R., Lauffenburger, Douglas A., Wittrup, K. Dane, Irvine, Darrell J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5209798/
https://ncbi.nlm.nih.gov/pubmed/27775706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4200
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