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Oxidative stress during acetaminophen hepatotoxicity: Sources, pathophysiological role and therapeutic potential

Acetaminophen (APAP) hepatotoxicity is characterized by an extensive oxidative stress. However, its source, pathophysiological role and possible therapeutic potential if targeted, have been controversially described. Earlier studies argued for cytochrome P450-generated reactive oxygen species (ROS)...

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Bibliografiska uppgifter
I publikationen:Redox Biol
Huvudupphovsmän: Du, Kuo, Ramachandran, Anup, Jaeschke, Hartmut
Materialtyp: Artigo
Språk:Inglês
Publicerad: Elsevier 2016
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5065645/
https://ncbi.nlm.nih.gov/pubmed/27744120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2016.10.001
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