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Mechanisms and Pathophysiological Significance of Sterile Inflammation during Acetaminophen Hepatotoxicity

Acetaminophen (APAP) is a widely used analgesic drug, which can cause severe liver injury after an overdose. The intracellular signaling mechanisms of APAP-induced cell death such as reactive metabolite formation, mitochondrial dysfunction and nuclear DNA fragmentation have been extensively studied....

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Detalhes bibliográficos
Publicado no:Food Chem Toxicol
Main Authors: Jaeschke, Hartmut, Ramachandran, Anup
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7098420/
https://ncbi.nlm.nih.gov/pubmed/32145352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.fct.2020.111240
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