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Acetaminophen hepatotoxicity and repair: the role of sterile inflammation and innate immunity
Acetaminophen (APAP) hepatotoxicity because of overdose is the most frequent cause of acute liver failure in the western world. Metabolic activation of APAP and protein adduct formation, mitochondrial dysfunction, oxidant stress, peroxynitrite formation and nuclear DNA fragmentation are critical int...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3586825/ https://ncbi.nlm.nih.gov/pubmed/21745276 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1478-3231.2011.02501.x |
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