Cyp2c44 gene disruption exacerbated pulmonary hypertension and heart failure in female but not male mice

Abstract. Epoxyeicosatrienoicacids (EETs), synthesized from arachidonic acid by epoxygenases of the CYP2C and CYP2J gene subfamilies, contribute to hypoxic pulmonary vasoconstriction (HPV) in mice. Despite their roles in HPV, it is controversial whether EETs mediate or ameliorate pulmonary hypertens...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Pulm Circ
Auteurs principaux: Joshi, Sachindra Raj, Lakhkar, Anand, Dhagia, Vidhi, Zias, Ariadne L., Soldatos, Vasiliki, Oshima, Kaori, Jiang, Houli, Gotlinger, Katherine, Capdevila, Jorge H., Schwartzman, Michal L., McMurtry, Ivan F., Gupte, Sachin A.
Format: Artigo
Langue:Inglês
Publié: University of Chicago Press 2016
Sujets:
Original Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5019089/
https://ncbi.nlm.nih.gov/pubmed/27683613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1086/688060
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires