Cyp2c44 gene disruption exacerbated pulmonary hypertension and heart failure in female but not male mice

Abstract. Epoxyeicosatrienoicacids (EETs), synthesized from arachidonic acid by epoxygenases of the CYP2C and CYP2J gene subfamilies, contribute to hypoxic pulmonary vasoconstriction (HPV) in mice. Despite their roles in HPV, it is controversial whether EETs mediate or ameliorate pulmonary hypertens...

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Detalhes bibliográficos
Publicado no:Pulm Circ
Main Authors: Joshi, Sachindra Raj, Lakhkar, Anand, Dhagia, Vidhi, Zias, Ariadne L., Soldatos, Vasiliki, Oshima, Kaori, Jiang, Houli, Gotlinger, Katherine, Capdevila, Jorge H., Schwartzman, Michal L., McMurtry, Ivan F., Gupte, Sachin A.
Formato: Artigo
Idioma:Inglês
Publicado em: University of Chicago Press 2016
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5019089/
https://ncbi.nlm.nih.gov/pubmed/27683613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1086/688060
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