Cyp2c44 gene disruption exacerbated pulmonary hypertension and heart failure in female but not male mice

Abstract. Epoxyeicosatrienoicacids (EETs), synthesized from arachidonic acid by epoxygenases of the CYP2C and CYP2J gene subfamilies, contribute to hypoxic pulmonary vasoconstriction (HPV) in mice. Despite their roles in HPV, it is controversial whether EETs mediate or ameliorate pulmonary hypertens...

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Vydáno v:Pulm Circ
Hlavní autoři: Joshi, Sachindra Raj, Lakhkar, Anand, Dhagia, Vidhi, Zias, Ariadne L., Soldatos, Vasiliki, Oshima, Kaori, Jiang, Houli, Gotlinger, Katherine, Capdevila, Jorge H., Schwartzman, Michal L., McMurtry, Ivan F., Gupte, Sachin A.
Médium: Artigo
Jazyk:Inglês
Vydáno: University of Chicago Press 2016
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5019089/
https://ncbi.nlm.nih.gov/pubmed/27683613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1086/688060
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