MicroRNA-140 is elevated and mitofusin-1 is downregulated in the right ventricle of the Sugen5416/hypoxia/normoxia model of pulmonary arterial hypertension.

Heart failure, a major cause of morbidity and mortality in patients with pulmonary arterial hypertension (PAH), is an outcome of complex biochemical processes. In this study, we determined changes in microRNAs (miRs) in the right and left ventricles of normal and PAH rats. Using an unbiased quantita...

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Veröffentlicht in:Am J Physiol Heart Circ Physiol
Hauptverfasser: Joshi, Sachindra Raj, Dhagia, Vidhi, Gairhe, Salina, Edwards, John G., McMurtry, Ivan F., Gupte, Sachin A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2016
Schlagworte:
Integrative Cardiovascular Physiology and Pathophysiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7199238/
https://ncbi.nlm.nih.gov/pubmed/27422986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00264.2016
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