Role of the Aryl Hydrocarbon Receptor in Sugen 5416–induced Experimental Pulmonary Hypertension

Rats dosed with the vascular endothelial growth factor inhibitor Sugen 5416 (Su), subjected to hypoxia, and then restored to normoxia have become a widely used model of pulmonary arterial hypertension (PAH). However, the mechanism by which Su exacerbates pulmonary hypertension is unclear. We investi...

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Bibliographic Details
Published in:Am J Respir Cell Mol Biol
Main Authors: Dean, Afshan, Gregorc, Teja, Docherty, Craig K., Harvey, Katie Y., Nilsen, Margaret, Morrell, Nicholas W., MacLean, Margaret R.
Format: Artigo
Language:Inglês
Published: American Thoracic Society 2018
Subjects:
Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5854960/
https://ncbi.nlm.nih.gov/pubmed/28956952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2017-0260OC
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