Involvement of gap junctions between smooth muscle cells in sustained hypoxic pulmonary vasoconstriction development: a potential role for 15-HETE and 20-HETE

In response to hypoxia, the pulmonary artery normally constricts to maintain optimal ventilation-perfusion matching in the lung, but chronic hypoxia leads to the development of pulmonary hypertension. The mechanisms of sustained hypoxic pulmonary vasoconstriction (HPV) remain unclear. The aim of thi...

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Publicat a:Am J Physiol Lung Cell Mol Physiol
Autors principals: Kizub, Igor V., Lakhkar, Anand, Dhagia, Vidhi, Joshi, Sachindra R., Jiang, Houli, Wolin, Michael S., Falck, John R., Koduru, Sreenivasulu Reddy, Errabelli, Ramu, Jacobs, Elizabeth R., Schwartzman, Michal L., Gupte, Sachin A.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2016
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4836112/
https://ncbi.nlm.nih.gov/pubmed/26895643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00377.2015
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