Rotenone-stimulated superoxide release from mitochondrial complex I acutely augments L-type Ca(2+) current in A7r5 aortic smooth muscle cells

Voltage-gated L-type Ca(2+) current (I(Ca,L)) induces contraction of arterial smooth muscle cells (ASMCs), and I(Ca,L) is increased by H(2)O(2) in ASMCs. Superoxide released from the mitochondrial respiratory chain (MRC) is dismutated to H(2)O(2). We studied whether superoxide per se acutely modulat...

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Bibliografiset tiedot
Julkaisussa:Am J Physiol Heart Circ Physiol
Päätekijät: Ochi, Rikuo, Dhagia, Vidhi, Lakhkar, Anand, Patel, Dhara, Wolin, Michael S., Gupte, Sachin A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Physiological Society 2016
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Call for Papers
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4888567/
https://ncbi.nlm.nih.gov/pubmed/26873970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00889.2015
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