Rotenone-stimulated superoxide release from mitochondrial complex I acutely augments L-type Ca(2+) current in A7r5 aortic smooth muscle cells

Voltage-gated L-type Ca(2+) current (I(Ca,L)) induces contraction of arterial smooth muscle cells (ASMCs), and I(Ca,L) is increased by H(2)O(2) in ASMCs. Superoxide released from the mitochondrial respiratory chain (MRC) is dismutated to H(2)O(2). We studied whether superoxide per se acutely modulat...

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Detalhes bibliográficos
Publicado no:Am J Physiol Heart Circ Physiol
Main Authors: Ochi, Rikuo, Dhagia, Vidhi, Lakhkar, Anand, Patel, Dhara, Wolin, Michael S., Gupte, Sachin A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4888567/
https://ncbi.nlm.nih.gov/pubmed/26873970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00889.2015
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