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Glucose-6-phosphate dehydrogenase increases Ca(2+) currents by interacting with Ca(v)1.2 and reducing intrinsic inactivation of the L-type calcium channel

Pyridine nucleotides, such as NADPH and NADH, are emerging as critical players in the regulation of heart and vascular function. Glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme in the pentose phosphate pathway, is the primary source and regulator of cellular NADPH. In the current...

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Detalhes bibliográficos
Publicado no:Am J Physiol Heart Circ Physiol
Main Authors: Gupte, Rakhee, Dhagia, Vidhi, Rocic, Petra, Ochi, Rikuo, Gupte, Sachin A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7474437/
https://ncbi.nlm.nih.gov/pubmed/32442021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00727.2019
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