20-HETE-induced mitochondrial superoxide production and inflammatory phenotype in vascular smooth muscle is prevented by glucose-6-phosphate dehydrogenase inhibition

20-Hydroxyeicosatetraeonic acid (20-HETE) produced by cytochrome P-450 monooxygenases in NADPH-dependent manner is proinflammatory, and it contributes to the pathogenesis of systemic and pulmonary hypertension. In this study, we tested the hypothesis that inhibition of glucose-6-phosphate dehydrogen...

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Veröffentlicht in:Am J Physiol Heart Circ Physiol
Hauptverfasser: Lakhkar, Anand, Dhagia, Vidhi, Joshi, Sachindra Raj, Gotlinger, Katherine, Patel, Dhara, Sun, Dong, Wolin, Michael S., Schwartzman, Michal L., Gupte, Sachin A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2016
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4867393/
https://ncbi.nlm.nih.gov/pubmed/26921441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00961.2015
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