Potential role of mitochondrial superoxide decreasing ferrochelatase and heme in coronary artery soluble guanylate cyclase depletion by angiotensin II

Oxidation of the soluble guanylate cyclase (sGC) heme promotes loss of regulation by nitric oxide (NO) and depletion of sGC. We hypothesized that angiotensin II (ANG II) stimulation of mitochondrial superoxide by its type 1 receptor could function as a potential inhibitor of heme biosynthesis by fer...

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Publicat a:Am J Physiol Heart Circ Physiol
Autors principals: Patel, Dhara, Alhawaj, Raed, Kelly, Melissa R., Accarino, John J. O., Lakhkar, Anand, Gupte, Sachin A., Sun, Dong, Wolin, Michael S.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2016
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4935518/
https://ncbi.nlm.nih.gov/pubmed/27037373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00859.2015
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