Potential role of mitochondrial superoxide decreasing ferrochelatase and heme in coronary artery soluble guanylate cyclase depletion by angiotensin II

Oxidation of the soluble guanylate cyclase (sGC) heme promotes loss of regulation by nitric oxide (NO) and depletion of sGC. We hypothesized that angiotensin II (ANG II) stimulation of mitochondrial superoxide by its type 1 receptor could function as a potential inhibitor of heme biosynthesis by fer...

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Bibliografske podrobnosti
izdano v:Am J Physiol Heart Circ Physiol
Main Authors: Patel, Dhara, Alhawaj, Raed, Kelly, Melissa R., Accarino, John J. O., Lakhkar, Anand, Gupte, Sachin A., Sun, Dong, Wolin, Michael S.
Format: Artigo
Jezik:Inglês
Izdano: American Physiological Society 2016
Teme:
Call for Papers
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4935518/
https://ncbi.nlm.nih.gov/pubmed/27037373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00859.2015
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