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Induction of ACE and activation of the RAS contribute to 20-HETE-mediated endothelial dysfunction
OBJECTIVE: 20-HETE promotes endothelial dysfunction by uncoupling eNOS, stimulating O(2)(−) production and reducing NO bioavailability. Moreover, 20-HETE-dependent vascular dysfunction and hypertension are associated with upregulation of the renin-angiotensin system (RAS). This study was undertaken...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3418056/ https://ncbi.nlm.nih.gov/pubmed/22723444 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.112.248344 |
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