Elevated 20-HETE impairs coronary collateral growth in metabolic syndrome via endothelial dysfunction

Coronary collateral growth (CCG) is impaired in metabolic syndrome (MetS). microRNA-145 (miR-145-Adv) delivery to our rat model of MetS (JCR) completely restored and neutrophil depletion significantly improved CCG. We determined whether low endogenous levels of miR-145 in MetS allowed for elevated p...

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Pubblicato in:Am J Physiol Heart Circ Physiol
Autori principali: Joseph, Gregory, Soler, Amanda, Hutcheson, Rebecca, Hunter, Ian, Bradford, Chastity, Hutcheson, Brenda, Gotlinger, Katherine H., Jiang, Houli, Falck, John R., Proctor, Spencer, Schwartzman, Michal Laniado, Rocic, Petra
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5402017/
https://ncbi.nlm.nih.gov/pubmed/28011587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00561.2016
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