Cyp2c44 gene disruption is associated with increased hematopoietic stem cells: implication in chronic hypoxia-induced pulmonary hypertension

We have recently demonstrated that disruption of the murine cytochrome P-450 2c44 gene (Cyp2c44) exacerbates chronic hypoxia-induced pulmonary artery remodeling and hypertension in mice. Subsequently, we serendipitously found that Cyp2c44 gene disruption also increases hematopoietic stem cell (HSC)...

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Detalhes bibliográficos
Publicado no:Am J Physiol Heart Circ Physiol
Main Authors: Hashimoto, Ryota, Joshi, Sachindra Raj, Jiang, Houli, Capdevila, Jorge H., McMurtry, Ivan F., Laniado Schwartzman, Michal, Gupte, Sachin A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5582928/
https://ncbi.nlm.nih.gov/pubmed/28550179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00785.2016
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