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Hypoxia-induced glucose-6-phosphate dehydrogenase overexpression and -activation in pulmonary artery smooth muscle cells: implication in pulmonary hypertension

Severe pulmonary hypertension is a debilitating disease with an alarmingly low 5-yr life expectancy. Hypoxia, one of the causes of pulmonary hypertension, elicits constriction and remodeling of the pulmonary arteries. We now know that pulmonary arterial remodeling is a consequence of hyperplasia and...

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Publicat a:Am J Physiol Lung Cell Mol Physiol
Autors principals: Chettimada, Sukrutha, Gupte, Rakhee, Rawat, Dhwajbahadur, Gebb, Sarah A., McMurtry, Ivan F., Gupte, Sachin A.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4338932/
https://ncbi.nlm.nih.gov/pubmed/25480333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00229.2014
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