Unique and shared signaling pathways cooperate to regulate the differentiation of human CD4(+) T cells into distinct effector subsets

Naive CD4(+) T cells differentiate into specific effector subsets—Th1, Th2, Th17, and T follicular helper (Tfh)—that provide immunity against pathogen infection. The signaling pathways involved in generating these effector cells are partially known. However, the effects of mutations underlying human...

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Veröffentlicht in:J Exp Med
Hauptverfasser: Ma, Cindy S., Wong, Natalie, Rao, Geetha, Nguyen, Akira, Avery, Danielle T., Payne, Kathryn, Torpy, James, O’Young, Patrick, Deenick, Elissa, Bustamante, Jacinta, Puel, Anne, Okada, Satoshi, Kobayashi, Masao, Martinez-Barricarte, Ruben, Elliott, Michael, Sebnem Kilic, Sara, El Baghdadi, Jamila, Minegishi, Yoshiyuki, Bousfiha, Aziz, Robertson, Nic, Hambleton, Sophie, Arkwright, Peter D., French, Martyn, Blincoe, Annaliesse K., Hsu, Peter, Campbell, Dianne E., Stormon, Michael O., Wong, Melanie, Adelstein, Stephen, Fulcher, David A., Cook, Matthew C., Stepensky, Polina, Boztug, Kaan, Beier, Rita, Ikincioğullari, Aydan, Ziegler, John B., Gray, Paul, Picard, Capucine, Boisson-Dupuis, Stéphanie, Phan, Tri Giang, Grimbacher, Bodo, Warnatz, Klaus, Holland, Steven M., Uzel, Gulbu, Casanova, Jean-Laurent, Tangye, Stuart G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2016
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Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4986526/
https://ncbi.nlm.nih.gov/pubmed/27401342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20151467
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