Monogenic mutations differentially impact the quantity and quality of T follicular helper cells in human primary immunodeficiencies

BACKGROUND: T follicular helper (Tfh) cells underpin T-cell dependent humoral immunity and the success of most vaccines. Tfh cells also contribute to human immune disorders such as autoimmunity, immunodeficiency and malignancy. Understanding the molecular requirements for the generation and function...

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Udgivet i:J Allergy Clin Immunol
Main Authors: Ma, Cindy S, Wong, Natalie, Rao, Geetha, Avery, Danielle T, Torpy, James, Hambridge, Thomas, Bustamante, Jacinta, Okada, Satoshi, Stoddard, Jennifer L, Deenick, Elissa K, Pelham, Simon J, Payne, Katherine, Boisson-Dupuis, Stéphanie, Puel, Anne, Kobayashi, Masao, Arkwright, Peter D, Kilic, Sara Sebnem, Baghdadi, Jamila El, Nonoyama, Shigeaki, Minegishi, Yoshiyuki, Mahdaviani, Seyed Alireza, Mansouri, Davood, Bousfiha, Aziz, Blincoe, Annaliesse K, French, Martyn A, Hsu, Peter, Campbell, Dianne E., Stormon, Michael O, Wong, Melanie, Adelstein, Stephen, Smart, Joanne M, Fulcher, David A, Cook, Matthew C, Phan, Tri G, Stepensky, Polina, Boztug, Kaan, Kansu, Aydan, Ikincioğullari, Aydan, Baumann, Ulrich, Beier, Rita, Roscioli, Tony, Ziegler, John B, Gray, Paul, Picard, Capucine, Grimbacher, Bodo, Warnatz, Klaus, Holland, Steven M, Casanova, Jean-Laurent, Uzel, Gulbu, Tangye, Stuart G
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5042203/
https://ncbi.nlm.nih.gov/pubmed/26162572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2015.05.036
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