IL-21 signalling via STAT3 primes human naïve B cells to respond to IL-2 to enhance their differentiation into plasmablasts

B-cell responses are guided by the integration of signals through the B-cell receptor (BCR), CD40, and cytokine receptors. The common γ chain (γc)-binding cytokine interleukin (IL)-21 drives humoral immune responses via STAT3-dependent induction of transcription factors required for plasma cell gene...

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Hauptverfasser: Berglund, Lucinda J., Avery, Danielle T., Ma, Cindy S., Moens, Leen, Deenick, Elissa K., Bustamante, Jacinta, Boisson-Dupuis, Stephanie, Wong, Melanie, Adelstein, Stephen, Arkwright, Peter D., Bacchetta, Rosa, Bezrodnik, Liliana, Dadi, Harjit, Roifman, Chaim M., Fulcher, David A., Ziegler, John B., Smart, Joanne M., Kobayashi, Masao, Picard, Capucine, Durandy, Anne, Cook, Matthew C., Casanova, Jean-Laurent, Uzel, Gulbu, Tangye, Stuart G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2013
Schlagworte:
Immunobiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3854113/
https://ncbi.nlm.nih.gov/pubmed/24159173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-06-506865
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