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Rapid activation receptor– or IL-2–induced lytic granule convergence in human natural killer cells requires Src, but not downstream signaling

Natural killer (NK) cells participate in host defense by surveying for and ultimately killing virally infected or malignant target cells. NK cell cytotoxicity is a tightly regulated process that proceeds stepwise from adhesion and activation to the secretion of preformed lytic granule contents onto...

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Hlavní autoři: James, Ashley Mentlik, Hsu, Hsiang-Ting, Dongre, Prachi, Uzel, Gulbu, Mace, Emily M., Banerjee, Pinaki P., Orange, Jordan S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3617630/
https://ncbi.nlm.nih.gov/pubmed/23380740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-06-437012
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