Natural Killer Cell Lytic Granule Secretion Occurs through a Pervasive Actin Network at the Immune Synapse

Accumulation of filamentous actin (F-actin) at the immunological synapse (IS) is a prerequisite for the cytotoxic function of natural killer (NK) cells. Subsequent to reorganization of the actin network, lytic granules polarize to the IS where their contents are secreted directly toward a target cel...

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Bibliographic Details
Main Authors: Rak, Gregory D., Mace, Emily M., Banerjee, Pinaki P., Svitkina, Tatyana, Orange, Jordan S.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3172191/
https://ncbi.nlm.nih.gov/pubmed/21931536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1001151
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