Naive and memory human B cells have distinct requirements for STAT3 activation to differentiate into antibody-secreting plasma cells

Long-lived antibody memory is mediated by the combined effects of long-lived plasma cells (PCs) and memory B cells generated in response to T cell–dependent antigens (Ags). IL-10 and IL-21 can activate multiple signaling pathways, including STAT1, STAT3, and STAT5; ERK; PI3K/Akt, and potently promot...

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محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Deenick, Elissa K., Avery, Danielle T., Chan, Anna, Berglund, Lucinda J., Ives, Megan L., Moens, Leen, Stoddard, Jennifer L., Bustamante, Jacinta, Boisson-Dupuis, Stephanie, Tsumura, Miyuki, Kobayashi, Masao, Arkwright, Peter D., Averbuch, Diana, Engelhard, Dan, Roesler, Joachim, Peake, Jane, Wong, Melanie, Adelstein, Stephen, Choo, Sharon, Smart, Joanne M., French, Martyn A., Fulcher, David A., Cook, Matthew C., Picard, Capucine, Durandy, Anne, Klein, Christoph, Holland, Steven M., Uzel, Gulbu, Casanova, Jean-Laurent, Ma, Cindy S., Tangye, Stuart G.
التنسيق: Artigo
اللغة:Inglês
منشور في: The Rockefeller University Press 2013
الموضوعات:
Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC3832925/
https://ncbi.nlm.nih.gov/pubmed/24218138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20130323
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