Naive and memory human B cells have distinct requirements for STAT3 activation to differentiate into antibody-secreting plasma cells

Long-lived antibody memory is mediated by the combined effects of long-lived plasma cells (PCs) and memory B cells generated in response to T cell–dependent antigens (Ags). IL-10 and IL-21 can activate multiple signaling pathways, including STAT1, STAT3, and STAT5; ERK; PI3K/Akt, and potently promot...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Deenick, Elissa K., Avery, Danielle T., Chan, Anna, Berglund, Lucinda J., Ives, Megan L., Moens, Leen, Stoddard, Jennifer L., Bustamante, Jacinta, Boisson-Dupuis, Stephanie, Tsumura, Miyuki, Kobayashi, Masao, Arkwright, Peter D., Averbuch, Diana, Engelhard, Dan, Roesler, Joachim, Peake, Jane, Wong, Melanie, Adelstein, Stephen, Choo, Sharon, Smart, Joanne M., French, Martyn A., Fulcher, David A., Cook, Matthew C., Picard, Capucine, Durandy, Anne, Klein, Christoph, Holland, Steven M., Uzel, Gulbu, Casanova, Jean-Laurent, Ma, Cindy S., Tangye, Stuart G.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Rockefeller University Press 2013
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3832925/
https://ncbi.nlm.nih.gov/pubmed/24218138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20130323
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