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Deletion of Mouse Rad9 Causes Abnormal Cellular Responses to DNA Damage, Genomic Instability, and Embryonic Lethality

The fission yeast Schizosaccharomyces pombe rad9 gene promotes cell survival through activation of cell cycle checkpoints induced by DNA damage. Mouse embryonic stem cells with a targeted deletion of Mrad9, the mouse ortholog of this gene, were created to evaluate its function in mammals. Mrad9(−/−)...

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Bibliografiset tiedot
Päätekijät: Hopkins, Kevin M., Auerbach, Wojtek, Wang, Xiang Yuan, Hande, M. Prakash, Hang, Haiying, Wolgemuth, Debra J., Joyner, Alexandra L., Lieberman, Howard B.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2004
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC479733/
https://ncbi.nlm.nih.gov/pubmed/15282322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.16.7235-7248.2004
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